Drugging the Cancers Addicted to DNA Repair
نویسندگان
چکیده
منابع مشابه
Drugging the Cancers Addicted to DNA Repair
Defects in DNA repair can result in oncogenic genomic instability. Cancers occurring from DNA repair defects were once thought to be limited to rare inherited mutations (such as BRCA1 or 2). It now appears that a clinically significant fraction of cancers have acquired DNA repair defects. DNA repair pathways operate in related networks, and cancers arising from loss of one DNA repair component ...
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ژورنال
عنوان ژورنال: JNCI: Journal of the National Cancer Institute
سال: 2017
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djx059